Synthesis and biological activity of some triazole-bearing benzimidazole derivatives

Synthesis and Biological Evaluation of Some Novel Triazole Derivatives

A series of eighteen novel 2-[(4-amino-5pyridin-3-yl-4H-1,2,4-triazol-3-yl)thio]-N-(substituted phenyl) propanamides 3(a-i) and 2-[(4-amino-5-phenyl-4H-1,2,4-triazol-3-yl) thio]-N-(substituted phenyl) propanamides 5(a-i) were synthesized by reacting 4-amino-5-pyridin-3-yl-4H-1,2,4-triazole-3-thiol (2) and 4-amino-5-phenyl-4H1,2,4-triazole-3-thiol (4) with the respective 2-chloro-N-(substituted ...

Synthesis, Characterization Biological Screening of Some Novel Triazole Derivatives

Synthesis Antimicrobial Activity and Chemotherapeutic Potential some Novel Benzimidazole Derivatives

Benzimidazole derivates play vital role in biological field such as antimicrobial, antiviral, antidiabetic, and anticancer activity. Therapeutic significance of these clinically useful drugs in treatment of microbial infections encouraged the development of some more potent and significant compounds. With the purpose of finding new chemical entities with enhanced antimicrobial activity, a serie...

Synthesis and Antimycobacterial Activity of some Triazole Derivatives–New Route to Functionalized Triazolopyridazines

A series of cyclic analogues of bioactive thiosemicarbazide derivatives have been synthesized as potential antimycobacterial agents. The 4-amino-1,2,4-triazole-5-thione analogues (Ia-f) were prepared by heating a mixture of thiocarbohydrzide and appropriate carboxylic acids. Reaction of thiocarbohydrazide with γ-ketoesters in the presence of sodium methoxide furnished triazolopyridazine derivat...

Synthesis and Antimycobacterial Activity of some Triazole Derivatives–New Route to Functionalized Triazolopyridazines

A series of cyclic analogues of bioactive thiosemicarbazide derivatives have been synthesized as potential antimycobacterial agents. The 4-amino-1,2,4-triazole-5-thione analogues (Ia-f) were prepared by heating a mixture of thiocarbohydrzide and appropriate carboxylic acids. Reaction of thiocarbohydrazide with γ-ketoesters in the presence of sodium methoxide furnished triazolopyridazine derivat...